Human Spermatozoa Quantitative Proteomic Signature Classifies Normo- and Asthenozoospermia
نویسندگان
چکیده
منابع مشابه
Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals
Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In the present review, we briefly reviewed the proteome of spermatozoa and seminal plasma in asthenozoospermia and considered post-translational modifications in spermatozoa of asthenozoospe...
متن کاملProteomic analysis of human spermatozoa proteins with oxidative stress
BACKGROUND Oxidative stress plays a key role in the etiology of male infertility. Significant alterations in the sperm proteome are associated with poor semen quality. The aim of the present study was to examine if elevated levels of reactive oxygen species cause an alteration in the proteomic profile of spermatozoa. METHODS This prospective study consisted of 52 subjects: 32 infertile men an...
متن کاملAn expression signature classifies chemotherapy-resistant pediatric osteosarcoma.
Osteosarcoma is the most common malignant bone tumor in children. Osteosarcoma patients who respond poorly to chemotherapy are at a higher risk of relapse and adverse outcome. Therefore, it was the aim of this study to identify prognostic factors at the time of diagnosis to characterize the genes predictive of poor survival outcome and to identify potential novel therapeutic targets. Expression...
متن کاملA gene expression signature that classifies human atherosclerotic plaque by relative inflammation status.
BACKGROUND Atherosclerosis is a complex disease requiring improvements in diagnostic techniques and therapeutic treatments. Both improvements will be facilitated by greater exploration of the biology of atherosclerotic plaque. To this end, we carried out large-scale gene expression analysis of human atherosclerotic lesions. METHODS AND RESULTS Whole genome expression analysis of 101 plaques f...
متن کاملDeciphering the proteomic signature of human endometrial receptivity.
STUDY QUESTION Are there any proteomic differences between receptive (R) and non-receptive (NR) endometrial receptivity array (ERA)-diagnosed endometria obtained on the same day of a hormonal replacement therapy (HRT) treatment cycle? SUMMARY ANSWER There is a different proteomic signature between R and NR ERA-diagnosed endometrium obtained on the same day of HRT cycles. WHAT IS KNOWN ALREA...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2017
ISSN: 1535-9476
DOI: 10.1074/mcp.m116.061028